FML - F**k My Life
It is an annoying Internet Slang, used most often in a situation where a person want to express great pressure and frustration. It gained popularity from the movie 'Superbad' in which a fat Mexican woman hates her life and want to express her frustration using this phrase.
Like in a conversation :
Person 1 : How's your studies going on?
Person 2 : Not good man
Person 2 : I need to complete 3 subjects this week.
Person 2 : FML !!
FML - FluoroMethoLone
It is a corticosteroid, marketed under the brand names FML (Allergan) and Flarex (Alcon), most often used after laser-based refractive surgery.